Epigenetics In Transgenerational Responses To Environmental Impacts: Facts And Gaps ebook.ecog-obesity.eu/chapter-biology/epigenetics-in-transgenerational-responses-to-environmental- impacts-facts-and-gaps
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Developmental origins of epigenetic transgenerational inheritance
Environmental factors can induce epigenetic alterations in the germ cells that can potentially be transmitted transgenerationally. This non-genetic form of inheritance is termed epigenetic transgenerational inheritance and has been shown in a variety of species including plants, flies, worms, fish, rodents, pigs, and humans. This phenomenon operates during specific critical windows of exposure,...
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A variety of environmental factors have been shown to induce the epigenetic transgenerational inheritance of disease and phenotypic variation. This involves the germline transmission of epigenetic information between generations. Exposure specific transgenerational sperm epimutations have been previously observed. The current study was designed to investigate the potential role genetic mutation...
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Environmental epigenetics has an important role in regulating phenotype formation or disease etiology. The ability of environmental factors and exposures early in life to alter somatic cell epigenomes and subsequent development is a critical factor in how environment affects biology. Environmental epigenetics provides a molecular mechanism to explain long term effects of environment on the deve...
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Chapter Outline Introduction 371 Epigenetics and Behavioral Biology 374 Epigenotypes Versus Epiphenotypes (Molecular vs. Molar Epigenetics) 375 The Epigenotype or Molecular Epigenetics 375 The Epiphenotype or Molar Epigenetics 376 Context-Dependent vs. Germline-Dependent Epigenetic Modifications 376 Context-Dependent Epigenetic Modification 377 Germline-Dependent Epigenetic Modification 378 Tra...
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One of the most important environmental factors to promote epigenetic alterations in an individual is nutrition and exposure to plant compounds. Phytoestrogens and other phytochemicals have dramatic effects on cellular signaling events, so have the capacity to dramatically alter developmental and physiological events. Epigenetics provides one of the more critical molecular mechanisms for enviro...
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